The aim of present work is to develop an accurate and sensitive novel method for the determination
of theophylline in pharmaceutical drugs. The complex formation between copper(II) and theophylline was
studied in methanolic media. Complex formation depends on reaction conditions at different metal-toligand
molar ratios. The mononuclear violet complex Cu(Theophylline)4 contains four ligands in a neutral
form bound monodentately (through the nitrogen) with an octahedral geometry. The new analytical
method based on measuring absorbance in UV-visible at λmax 400nm. Optimum pH was estimated.
Linearity (40-250), detection limits 07*10-7M. were determined. The complex was characterized with
UVvisible
and IR spectra in addition of CHNM analysis. The molar ratio also investigated and found
1:4(Cu: Theophylline).
Key words: Characterization, copper, metal complex and Theophylline.
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